Homework_02_solution - BME 402 Ion channels Homework 2 Due...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
BME 402 Homework 2 Due 11am, 1/31/06 Ion channels Ion channels are among the most important molecules in living organisms, and certainly in the brain. The are involved in all neural signaling, including the establishment of the resting membrane potential, and all voltage signaling on top of that. Many drugs (and toxins) act on ion channels, often mimicking the action of endogenous neurochemicals. Know their range of atomic weights, and the basic physical structure (i.e. be able to draw an ion channel in schematic form). Know a few examples of one or more drugs that act on ion channels, and one or more neurotoxins, and be able to state how the drug or toxin affects the channel and how that translates into a change in the behavior of the animal. Understand basics of ion flow through a channel: is it active or passive, what are basic mechanisms of selectivity, how many ions can flow per second. Be able to draw a typical current trace of an ion channel opening and closing with time. Be able to list 4 types of gating of ion channels. Membrane potential Be able to explain how the resting potential comes about as a result of the ionic concentration gradients and selective permeability that exist across the bilipid membrane. Specifically, you should memorize (1) the Nernst equation including the constants at 37degC, (2) the GHK equation for the membrane potential, and (3) the simpler weighted- average-of-batteries equation for the steady state membrane potential. For the four main current-carrying ions in the brain (know their names), know which way the concentration gradients point (higher inside or outside), and whether the ion contributes to a more positive or more negative membrane potential. Understand the reason for and effect of the Na+/K+ pump, and know what it means for an ion to be passively distributed. Know Ohm's law, and the law relating charge to voltage on a capacitor.
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern