Alimentary viruses continued
Coxsackievirus A & B•A – typically rashes; B internal symptoms•Meningitis “aseptic” - A and B (summer/fall)•Herpeangina –A (mouth/tongue)•Hand, foot & mouth disease -A•Myocarditis – B•Or mild respiratory “cold type” symptoms that often go undiagnosed
Meningitis•Meningitis = inflammation of the meninges surrounding the spinal cord and brain•Inflammation caused by infection of the fluid surrounding the spinal cord and brain
Causes•Bacterial infection•Viral infection-headache, stiff neck, fever and general malaise, possibly vomiting, enteroviruses very common cause of viral meningitis•Fungal infection- less common cause; causes chronic meningitis•Physical injury•Cancer•Certain drugs
Bacterial vs. ViralBacterial Meningitis•rare cause of meningitis•most serious- life threatening•may result in death or brain damage even if treatedViral meningitis•most common cause of meningitis•usually mild•often clears on its own within 2 weeks•Complications - encephalitis
Symptoms•Signs and symptoms develop over several hours or over one or two days•In anyone over age 2, see sudden onset of:•Fever•Severe headache (characteristic symptom)•Stiff neck (characteristic symptom)•Vomiting or nausea with headache (characteristic symptom)•Confusion or difficulty concentrating•Seizures•Sleepiness or difficulty waking up•Sensitivity to light•Lack of interest in drinking and eating•Sometimes skin rash
ENCEPHALITIS•Encephalitis is irritation and swelling (inflammation) of the brain, most often due to infections.
Viral Encephalitides: Symptoms•Most people have no symptoms.•If symptoms are present, they include:•FEVER, HEADACHE, VOMITING, STIFF NECK, DROWSINESS, COMA, PARALYSIS, INCOORDINATION, PSYCHOSES
Hepatitis•Inflammation of the ????•Hepatitis infections (A, B, C, D, E,) have different causes and routes of transmission•A/E – fecal/oral transmission (typically acute infection)•B/C – “serum” (transfusion, needle stick), sexual transmission, can have acute stage and may become a chronic infection
HepatitisHepatitis APicornavirus +ssRNA“infectious hepatitis” fecal-oral, foodborne0.5% mortality, not chronic, no cancerHepatitis ECalcivirus + ssRNAnaked“enteric” hepatitis, fecal oral, often foodborneMild disease 1-2% mortality; pregnant patient 20% mortality, not chronic no cancerHepatitis BHepadnavirus ds DNAEnveloped – but resistant“serum” hepatitisParenteral or sexual transmission, insidious onset, 1-2% mortality, assoc w carcinoma, cirrhosisHepatitis CFlaviviradea + ssRNAenveloped“post-transfusion hepatitis, parenteral or sexual t. acute disease subclinical but chronicity with mortality, assoc w carcinoma, cirrhosisHepatitis DDefective RNA virus require Hep B to grow“co-infection” severe1stB, then B&D high mortality
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- Fall '16
- Hepatitis A, Hepatitis D, Hepatitis C