HW+4key - Class number Homework #4: Protein sorting and...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Class number Homework #4: Protein sorting and membrane trafficking 1. Please complete the concept map
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Class number 2. List 2 similarities and 2 differences between the mechanism of protein import into the nucleus and into the ER. Similarities: signal-mediated (signal is contained within the primary amino acid sequence) Signal is recognized by a receptor (importin vs SRP) Translocation machinery that generates an aqueous pore in the membrane Differences: fully-folded proteins can be imported into the nucleus while proteins are imported into the ER are unfolded (or still being synthesized by the ribosome = co-translational) Nuclear import requires the activity of a small GTPase (Ran) Driving force is protein synthesis for ER import, GTP –Ran binding in the nucleus The nuclear pore is always open, ER translocon is gated 3. You have obtained the following sequence information of a novel integral protein of the plasma membrane. A) Draw how this protein would be inserted into the membrane. (Please label the N-terminus, C-
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 4

HW+4key - Class number Homework #4: Protein sorting and...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online