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Unformatted text preview: -tangles inside neurons themselves-new compound needs to be able to get past blood-brain barrier and stay long enough to do scan to show plaques and clear out quick enough to use on living patients-amyloid buildup becomes toxic in brain-same plaques as down syndrome (extra copy of chromosome 21)-APP protein can maintain synapses, memories; clips not at surface but just above n below beta amyloid-genetic mutations cause less than 5% of alzheimers-pittsburgh compound- got into brain stuck to plaques and cleared them away-goal to predict early in life who might get alzheimers Shens notes-paranoia, anger, temper tantrums-causes-genetics (usually early-onset, chromosome 21)-impacts- caretaking is huge burden (look on psychological issues-higher incidence for heart disease)-use Massachusetts microscope Also delirium, dementia, cognitive disorders...
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This note was uploaded on 06/01/2008 for the course PSYC 360 taught by Professor Borders during the Spring '07 term at USC.
- Spring '07
- Abnormal Psychology