BS1005 Computer Lab 3 - BS1005 computer practical 3...

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BS1005 computer practical 3 Visualization and analysis of myoglobin and hemoglobin The aim of the practical is to visualize myoglobin and hemoglobin molecules and analyze the structural properties of the proteins. Exercise 1 : Analysis of the heme group of myoglobin in ligand-free form and in complex with molecular oxygen. Coordination compounds play important roles in animals and plants by forming complex with regulatory proteins such as hemoglobin and myoglobin. Hemoglobin transports oxygen in the blood from the lung to the tissues, where it delivers oxygen to myoglobin. Myoglobin stores oxygen for metabolic use. The heme (iron-porphyrin complex) is a central part of hemoglobin and myoglobin. Iron (Fe 2+ ) atom has six coordination bonds, four to the nitrogen atoms of porphyrin ring and one to a nitrogen donor atom from proximal F8 His . The sixth ligand is oxygen (oxy form) or water molecule (deoxy form). The binding of the ligand oxygen pulls the iron into the heme plane, and the heme becomes flat.
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