preworksheet9 - Genome 371 Quiz Section 9 Preworksheet...

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Genome 371 Quiz Section 9 –Preworksheet Genome Browsing and Human Disease Genes. Goal: To use internet resources to a) explore human genome organization and b) to understand how to find human disease gene orthologs in other organisms based on sequence-relatedness. Background: Homo sapiens is one twig on a complex tree of life that relates all animals to one another during evolution. We are particularly closely related to other placental mammals, some of which are important model organisms that geneticists study (e.g. Mus musculus (house mouse) and Canis familiaris (domestic dog)). Most genes in humans have exact counterpart genes in other vertebrates, which are called orthologous genes (or orthologs). Most orthologous genes have the same function in their respective species, so study of the ortholog of a human gene in a model organism sheds light on the function of the gene in both organisms. Several species of vertebrates have complete draft genome sequences available, including Homo sapiens , Pan troglodytes (chimpanzee), Mus musculus (house mouse), Rattus norvegicus (Norway rat), Canis familiaris (domestic dog), Gallus gallus (chicken), and Danio rerio (zebrafish). This means that if we have the sequence of a human disease gene we can use it to find the orthologous gene in these other species. Hundreds of human genes have been identified that cause disease in a simple Mendelian manner. Most of these diseases result from recessive loss-of-function mutations in a disease gene, and they cause disease when homozygous. We have compiled a list of disease genes. Each group will perform a detailed analysis of one of the genes. You will use on-line resources to find out about the human disease caused by your chosen gene, investigate its genome organization and identify the corresponding gene in other animals. Resources.
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This note was uploaded on 06/03/2008 for the course GENOME 371 taught by Professor Unsure during the Spring '03 term at University of Washington.

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preworksheet9 - Genome 371 Quiz Section 9 Preworksheet...

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