Chapter_03

Chapter_03 - Chapter 3 Mendelian (Transmission) Genetics...

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Chapter 3 Mendelian (Transmission) Genetics
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The 7 traits in garden pea studied by Mendel
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Molecular basis of the wrinkled seed coat mutation The wrinkled seed coat mutant is due to the insertion of a foreign sequence in the wild type smooth seed coat gene. As a consequence, the mutant gene is longer and runs slower in a size-separation gel.
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Results of a monogenic genetic cross (involving 2 alleles of the same gene)
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1 and 3:1 segregation in the F 2 generation A diagram like this is called a Punnett square
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2 3 while the wrinkled ones breed true
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Genetic and molecular explanation of a testcross
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Results of a dihybrid cross (involving alleles of 2 genes) The coat color gene and seed shape genes assort (segregate) independently
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Independent segregation of alleles of 2 genes leads to 4 kinds of gametes in equal proportions
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Random fertilization of the 4 kinds of gametes generates the 9:3:3:1 phenotypic ratio Punnett square for a dihybrid cross Genotype ratio Phenotype ratio
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2 The W gene is segregating 1 WW : 2 Ww : 1ww The G gene is also segregating 1 GG : 2 Gg : 1 gg
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1 (a testcross) yields a 1:1:1:1 ratio
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Statistical Analysis of Genetic Data- the X 2 test X 2  = Sum of [d 2 /e]   where d= Deviation = [Observed-Expected] and e= Expected value. Let us take the data of Mendel from the F 2  generation of  a  WWGG  x  wwgg  cross- 315 W-G-: 108 W-gg : 101 wwG-  : 32 wwgg   ( see p. 100 of the textbook ). A 9 : 3 : 3 : 1 ratio is expected, if the genes are assorting independently. In our case,  Phenotypes  = W-G-        W-gg wwG-        wwgg           Observed  =     315                 108  101                    32     Total = 556           Expected  =      313                 104                 104                    35                             (9/16 x 556)   (3/16 x 556)   (3/16 x 556)   (1/16 x 556)
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This note was uploaded on 06/09/2008 for the course CBN 356 taught by Professor Merill during the Spring '08 term at Rutgers.

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Chapter_03 - Chapter 3 Mendelian (Transmission) Genetics...

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