Lecture 12a - Supplementary Liver Pathology Slides (Interest Only)

Lecture 12a - Supplementary Liver Pathology Slides (Interest Only)

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Unformatted text preview: 1 Supplementary Liver Pathology Slides For your interest only- You will not be required to learn this material for the exam Bilirubin Metabolism Hemoglobin Globin Haem Bilirubin Liver Bile to Intestine 4 Jaundice (Yellow) Pre-Hepatic Hepatic Post-Hepatic Pre-Hepatic Jaundice Excess bilirubin production Due to a lot of RBCs undergoing hemolysis Hepatic (Hepatocellular) Jaundice Viral hepatitis Alcoholic liver disease Drug-Induced liver disease Cirrhosis Post-Hepatic Jaundice Obstructive Gall stones Cancer of pancreas Cancer of bile ducts 2 4 Acute Viral Hepatitis Caused by Viruses A B C (D E) Features of Hepatitis < 1% 1% < 1% Risk of Fulminant Hepatitis 15 - 150 40 180 15-45 Incubation (days) Parent/Sex Parent/Sex Fecal/Oral Transmission Long Long Brief Viremia Hep C Hep B Hep A Feature Features of Hepatitis No Yes Yes Vaccine ? Yes Yes No Carrier ? Yes (2-5%) Yes (10%) No Cancer Risk? 85 % 4 % No Chronicity Hep C Hep B Hep A Feature Hepatitis A Sources Sewage Contaminated food Shellfish Prevalent in children in underdeveloped countries Hepatitis A Symptoms after short incubation Clinical Vomiting Anorexia Jaundice Recovery within days 3 Hepatitis B Infection after exposure to blood, blood products (including unsterile needles), sexual activity Components generate at least three antigens HBsAg (Surface Antigen) HBcAg (Core Antigen) HBeAg ( e Antigen) Hepatitis B Clinical 40 180 days after infection Three phases Preicteric Icteric (jaundice present) Convalescent Pre-Icteric Phase Weakness Nausea & vomiting RUQ tenderness...
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This note was uploaded on 06/10/2008 for the course BIOL BIOL-1F25 taught by Professor Peery during the Spring '08 term at Brock University.

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Lecture 12a - Supplementary Liver Pathology Slides (Interest Only)

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