Lecture 13a - Supplementary Slides on the Thyroid

Lecture 13a - Supplementary Slides on the Thyroid - THE

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Lecture 13a: Supplementary Slides on the Thyroid These slides reinforce and repeat information given in Lecture 13. You will not be held responsible for them. There will be no questions on the exam based on these supplementary slides. ION TRANSPORT BY THE THYROID FOLLICULAR CELL I - I - organification Propylthiouracil ( PTU ) blocks iodination of thyroglobulin COLLOID BLOOD NaI symporter (NIS) Thyroid peroxidase (TPO) ClO 4 - , SCN - (perchlorate and thiocyanate) TSH TSH receptor Iodination of Tyr residues of Tg COLLOID TPO THYROGLOBULIN SYNTHESIS IN THE THYROID FOLLICULAR CELL Thyroid peroxidase Tg = thyroglobin Il ustration from Liddle, G. and Liddle, R. (1980) Endocrinology. in Smith, L.H.jr., and Their, S.O., eds. Pathophysiology. WB Saunders, Philadelphia, p. 708
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 THYROID HORMONE SECRETION BY THE THYROID FOLLICULAR CELL COLLOID TSH TSH receptor DIT MIT I - T 4 T 3 O H N 2 I T 4 R 3,3’-T 2 R T 3 “Step up” R rT 3 “Step down” THYROID HORMONE METABOLISM R = FEEDBACK REGULATION
Background image of page 2
Background image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: THE HYPOTHALAMIC-PITUITARY-THYROID AXIS Hormones derived from the pituitary that regulate the synthesis and/or secretion of other hormones are known as trophic hormones. Key players for the thyroid include: TRH-T hyrophin R eleasing H ormone TSH-T hyroid S timulating H ormone T 4 /T 3- Thyroid hormones Types of hyperthyroidism Il ustration from Liddle, G. and Liddle, R. (1980) Endocrinology. in Smith, L.H.jr., and Their, S.O., eds. Pathophysiology. WB Saunders, Philadelphia, p. 711 3 Types of hypothyroidism Il ustration from Liddle, G. and Liddle, R. (1980) Endocrinology. in Smith, L.H.jr., and Their, S.O., eds. Pathophysiology. WB Saunders, Philadelphia, p. 711 End of Supplementary Lecture 13a Slides You are not responsible for this material. No exam questions will be taken from this material....
View Full Document

Page1 / 3

Lecture 13a - Supplementary Slides on the Thyroid - THE

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online