Lecture 24 - Cancer - The Evidence

Lecture 24 - Cancer - The Evidence - Lecture 24 Background...

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1 Cancer: The Evidence Biology 1F25 for Biology Non-Majors Lecture 24 Background Reading Textbook, Chapter 19. The People Who Prepared This Lecture Harry Peery Alan Castle Biochemical Evidence
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2 Biochemical Evidence Cancerous cells produce several proteins not usually produced by non-cancerous cells from the same tissue. Biochemical Evidence Example: Invasion of surrounding tissues. Basal lamina (Basement membrane) Collagen
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Collagen Biochemical Evidence Cancerous cells produce “proteinases”, enzymes that breakdown proteins, in this case, collagen. This helps the cancerous cells pass through the basal lamina. Biochemical Evidence Also, one protein “plasminogen activator” is secreted by malignant cells into nearby capillaries. This protein converts “plasminogen” (another protein found in blood serum) into “plasmin”. Plasmin is another proteinase and works to digest the basal lamina from the circulation side of the basal lamina. Biochemical
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This note was uploaded on 06/10/2008 for the course BIOL BIOL-1F25 taught by Professor Peery during the Spring '08 term at Brock University, Canada.

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Lecture 24 - Cancer - The Evidence - Lecture 24 Background...

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