Lecture 26 - How Cancer Starts

Lecture 26 How - Lecture 26 Background Reading Textbook Chapter 19 Cancer How Cancer Starts Biology 1F25 for Biology Non-Majors Carl Sagan The

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Cancer: How Cancer Starts Biology 1F25 for Biology Non-Majors Lecture 26 Carl Sagan Background Reading Textbook, Chapter 19. The People Who Prepared This Lecture Harry Peery Alan Castle Carl Sagan was a professor of astronomy and astrochemistry at Cornell University. He wrote more than 600 scientific articles, scripted and narrated a popular astronomy program ( Cosmos, A Personal Voyage ) which explained the cosmos to more than 600 million people in 60 countries. He wrote books, his last being turned into a movie, Contact , staring Jodie Foster, which was finished after his death and was dedicated to him. He was also a believer and seeker of extraterrestrial life and as such, was threatened with death by several groups. He was forced to travel with bodyguards – even when lecturing in his class at Cornell.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Sagan with Viking Lander which he helped design– for landing on Mars. Sagan died at the relatively young age of 62 of myelodysplastic syndrome, a precancerous condition which destroys the bone marrow. It was formerly called preleukemia as a high percentage of patients progressed to acute myelogenous leukemia. Myelodysplasia showing abnormal cells that have replaced the normal blood forming cells in the bone marrow. There are a few cells that are highly dysplastic and may become the progenitors of cancer cells, most likely acute myelogenous leukemia From Illustrated Pathology of the Bone Marrow, by Orazi, O’Malley, and Arber, Cambridge University Press, 2006 Bone Marrow Sagan died from a failure of genes in his bone marrow How Cancer Starts
Background image of page 2
3 3 Events Occur to Cause Cancer - 1 • 1. Nonlethal genetic damage due to – Chemicals –Rad iat ion – Viruses – Inheritance The cells are not killed – just mutated. 3 Events Occur to Cause Cancer - 2 • 2. Principle targets of the genetic damage are 4 classes of regulatory genes: A. Proto-oncogene – growth promoting genes B. Antioncogenes – growth-inhibiting cancer-suppressing genes C. Genes that regulate programmed cell death (apoptosis) D. Genes that regulate the repair of DNA 3 Events Occur to Cause Cancer - 3 • 3. Multistep process by which a malignant neoplasm changes its genetics and observable features such as: – Excessive growth – Local invasiveness – Ability to form distant metastases Cancer Cells have altered the following Genes • Growth regulatory genes • Angiogenesis genes (genes that enhance blood vessel formation) • Invasion genes • Metastasis genes • Alter genes so cancer cells no longer age
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 6 Fundamental Changes in Cell Physiology in Cancer Cells • 1. Generate own continual growth signals • 2. Lose sensitivity to growth signals from other parts of body. • 3. Avoidance of apoptosis
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 06/10/2008 for the course BIOL BIOL-1F25 taught by Professor Peery during the Spring '08 term at Brock University, Canada.

Page1 / 11

Lecture 26 How - Lecture 26 Background Reading Textbook Chapter 19 Cancer How Cancer Starts Biology 1F25 for Biology Non-Majors Carl Sagan The

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online