Lecture 29 - Tumour Suppressor Genes

Lecture 29 - Tumour Suppressor Genes - Lecture 29...

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1 Tumour Suppressor Genes Biology 1F25 for Biology Non-Majors Lecture 29 Background Reading Textbook, Chapter 19. The People Who Prepared This Lecture Harry Peery Alan Castle Last lecture: The mutant oncogene allele is dominant to the non-mutant proto-oncogene allele. Mutation of only one of two proto-oncogene alleles to an oncogene allele is sufficient for that gene to contribute to cancer. Rb allele that contributes to cancer must become homozygous before it can contribute to cancer. The allele that contributes to cancer is recessive. Finley et al: p53-WT (normal allele) inhibited ras oncogene expression and mutant alleles from cancers did not.
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2 Next Question Finley et al. Which allele is dominant, the non-mutant allele p53-wt allele or the mutant alleles, p53- val135 or p53-KH215 ? Observation The non-mutant allele p53-wt still suppresses the ras oncogene in the same cell as either of the mutant alleles, p53-val135 or p53-KH215 . Conclusion: The non-mutant allele from non- cancerous cells is dominant to the mutant alleles from cancerous cells. As a result of this study genes such as p53 and Rb are now called “Tumour Suppressor Genes”.
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3 What is the normal function of tumour suppressor genes and their proteins? Normal Rb protein binds to and inactivates transcription factors (encoded by proto-oncogenes) which promote cell division. Rb, therefore, inhibits cell
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Lecture 29 - Tumour Suppressor Genes - Lecture 29...

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