lec3_pysiological_aging_and_sensory_changes_p - Lecture...

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Lecture 3 “LONGEVITY AND PHYSIOLOGICAL AGING” LIFE SPAN AND THE AGING PROCESS * Trends in life expectancy: * Life expectancy * Longevity The Concept of Age * Maximum life span: The longest that any member of a given species can live under ideal conditions - humans about 120 years, giant sea tortoise live about 160 years * Life Expectancy: How long, on average, one is expected to live, 1900à 50% born were expected to reach 50 * Survivor Effects: The phenomenon that members of a population that live the longest are expected to live even longer than those who did not survive * Gender and Life Expectancy: women live longer 1970 1985 2020 Woman: 71 78.2 82.0 Men: 65.5 71.2 74.2 * Why the gender difference? Health behavior habits, genetics (XX, XY), hormones (heart disease is caused by lack of estrogen=men and after medopause) * Ethnicity and Life Expectancy Men Women All 72.6 78.9 White 73.4 79.6 Black 65.4 74.0 LIFE SPAN AND THE AGING PROCESS * Predicting individual longevity * Biomarkers
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* Declines in immune system functioning * Blood levels of DHEA: immune disfunction, increase cancer, Heart Disease men, Ostiopersis. Women Biological Theories of Aging * Programmed Theories * senescence is directed by genetic factors (e.g., there are old age genes that are turned on later in life). * Random Event Theories * senescence is result of random or unplanned damage LIFE SPAN AND THE AGING PROCESS * Genetic-programming theories * Implies that environmental influences * Decline or failure may be from programmed senescence, when specifi genes “switch off” * Theories of biological aging * * Programmed senescence * Endocrine theory * Immunological theory * Telomere theory Support for Programmed Theories * Hayflick Limit: Limit # of times a cell will replicate Limits vary by species; limit in humans ~50 * Maximum life span of species differs * Manifestations of aging differ among species * Genetic mutations cause accelerated aging disorders (progeria, Downs syndrome)
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This note was uploaded on 06/10/2008 for the course HDE 100C taught by Professor Gabston during the Spring '08 term at UC Davis.

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lec3_pysiological_aging_and_sensory_changes_p - Lecture...

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