Bio_218_practice_quest_2

Bio_218_practice_quest_2 - Here are some more practice...

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Here are some more practice questions from an old final. I will probably use some of these questions for our final exam. Hope this helps. Bob Concepts/Mechanisms: 32 questions at 2.5 pts each 1. The functions associated with telomeres are to: a. ensure the appropriate segregation of chromosomes b. promote the fusion of chromosomal ends with other DNA molecules. c. prevent ribonucleases from degrading the ends of linear DNA molecules. d. facilitate replication of chromosomes without the addition of bases to the termini. e. None of the above 2. The double helical structure of DNA can adopt various forms. Which of the following statements are correct about the form in question? a. A-DNA is the conformation in a partially dehydrated environment b. B-DNA occurs under physiological conditions c. DNA-RNA duplexes exist in an B-form. d. B and Z are right handed helices, while A is left handed. e. The Z-form of DNA is found in A-T rich regions and has a defined role in vivo . 3. Eukaryotic chromosomes are organized: a. using histones due to their negative charges, which aids in their interaction with the charged phosphate backbone of DNA. b. in a multineme fashion, where each chromosome represents a single, continuous double helix. c. by two groups of RNAs, histones and nonhistone chromosomal RNAs. d. with histones as the basic unit of organization, an octamer of which comprises one nucleosome. e. all of the above. 4. Which of the following statements are incorrect about DNA structure? a. The two strands of a double helix are complementary and anti-parallel. b. X-ray diffraction patterns indicated a double-stranded structure with repeating substructure every 4.6 nm along the axis c. The structure was first predicted by Watson and Crick in 1953 to be arranged as a double-stranded helix. d. The final structure was consistent with Chargoff's rule. e. none of the above 5. The principle characteristics of nucleotides are: a. three types of 5-carbon sugars b. only one type of cyclic nitrogen base c. a phosphate group d. they are capable of forming large polypeptides e. a and b
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6. Eukaryotic chromosomal replication: a. occurs from a single origin.0 b. is bi-directional. c. has sequence-specific origins (termed autonomously replicating sequences). d. b and c e. all of the above. 7. Initiation of DNA replication involves: a. the requirement for a free 3’ PO 4 . b. the requirement for one primer on the leading strand c. the requirement for multiple primers on the leading strand d. DNA primase that produces DNA primers e. a single origin of replication in prokaryotes and eukaryotes. 8. In the work of Meselsohn and Stahl: a. the method of DNA replication was found to be conservative, indicating that the parental double helix is conserved and a new double helix is formed. b. the experiment used radioisotopes in conjunction with centrifugation to separate DNA
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This note was uploaded on 06/12/2008 for the course BIO 218 taught by Professor Castronuevo during the Spring '08 term at Drexel.

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Bio_218_practice_quest_2 - Here are some more practice...

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