Exam03-Key - Genetics 320 (EEB/MCB) TEST THREE NAME:_ KEY _...

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Genetics 320 (EEB/MCB) TEST THREE NAME:______ KEY ___________ WRITE YOUR NAME AT THE TOP OF EACH PAGE!! SHOW ALL WORK!! (1) [5 points ] Suppose 1000 gametes from a single parent are scored, and the following numbers are seen: 400 Ab , 410 aB , 90 AB , 100 ab . Are A and b linked? If so, what is the recombination fraction? Yes, c = (90+100)/1000 = 0.19 (2) [20 points ] You are using marker loci to look for a linked QTL and have a single large full-sib family. Three marker loci are considered, A, B, and C. The father has genotype A 1 A 2 B 1 B 2 C 2 C 2 , while the mother is A 3 A 2 B 1 B 2 C 1 C 1 . (a) Can all of these markers can be used to detect potential linkage? If some loci cannot be used, why is this so? The A and B marker loci can, however the C locus in homozygous in both parents and hence uninformative for linkage. (b) Suppose the mean value of the trait of interest in the offspring genotyped for marker A are as follows: A 1 A 3 15, A 1 A 2 25, A 2 A 2 45, A 2 A 3 55. Is there evidence that the marker is linked to a QTL? If a QTL found, is it segregating (i.e., a heterozygote) in the father? The Mother? Both? Father: A 1 = (15+25)/2 = 20; A 2 = (45+55)/2 = 50 ---> Evidence of a linked QTL, father QTL heterozygote Mother: A 3 = (15+55)/2 = 35; A 3 = (25+45)/2 = 35 ---> No evidence of a linked QTL, however, given father, mother is a QTL homoozygote (c) Suppose the mean value of the trait of interest in the offspring genotyped for marker
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Exam03-Key - Genetics 320 (EEB/MCB) TEST THREE NAME:_ KEY _...

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