exam2ted07 - 1. Cancer pathway. Short answers (10 points)...

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1. Cancer pathway. Short answers (10 points) Consider the cancer pathway shown below. a. In a p21-/- cell, list under each gene above whether each gene is ON or OFF (starting with p21, going to the right), and indicate the overall cell division response (Go or Stop). You are given the p21 answer (4 pt) b. Does a cancer cell usually have one gene mutated, or two in this pathway. For example, are cancer cells either p53 -/- Rb +/+ , or p53 +/+ Rb -/- , or are they p53 -/- Rb -/- . Why is that? (3pt) Usually only one gene is mutated, because the two genes are in the same pathway, and the cell has the same selective advantage for growth when either is mutant. The second mutation, were it to occur, does not infer in additional selective advantage; one is enough. c. In the cell shown below, an Rb+/- cell is converted to Rb-/- by a mitotic recombination event. The event to form Rb -/- could have been either by a gene conversion or a crossover event. Which event is more frequent?(1pt) Crossing over
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This note was uploaded on 06/16/2008 for the course ECOL 320 taught by Professor Weinert during the Spring '07 term at University of Arizona- Tucson.

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exam2ted07 - 1. Cancer pathway. Short answers (10 points)...

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