Mitotic Cell Division - MitoTc Cell Division Reasons for...

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Mitotic Cell Division: Reasons for mitotic cell division: 1) Repair and renewal (tissue renewal giving rise to new blood cells) 2) Growth and embryonic development (fertilized eggs) 3) Organismal reproduction (one cell division can reproduce and entire organism) Mitotic Cell Cycle: Overview Interphase: - G1 (gap 1) before DNA synthesis - S (DNA synthesis) - G2 (After DNA synthesis) - Mitotic phase: divided in two parts 1) Mitosis: division of the nucleus Karyokinesis 2) Cytokinesis: Cytoplasmic division During this phase the cells produced are smaller than the original phase, the cell gets bigger until it reaches the normal size, it grows by adding of additional organelles. Mitotic Cell Cycle – S phase. Before chromosome duplicate it consists of a single long and thin chromatin fiber containing one DNA molecule and associated proteins by a centromere. Chromosomes duplication (including DNA replication) and condensation: Once duplicated, chromatids are connected along their entire lengths by sister chromatids cohesion. Each chromatid contains a copy of the DNA molecule. Double Helix Separation of sister chromatids into two chromosomes: After cell division, the cell division, the cell divides into 2 cells of 1 chromatid, therefore 1 helix.
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Mitotic Cell Cycle – M Phase. G 2 of Interphase: - A nuclear envelope encloses the nucleus - The nucleus contains one or more nucleoli - 2 Chromosomes have formed by duplication of a single centrosome. Centrosomes are regions in animal cells that organize the microtubules of the spindle. Each centrosomes contains two centrioles. - Chromosomes, duplicated during S phase, cannot be seen individually because they have not yet condensed. Prophase: - The chromatin fibers become more tightly coiled, condensing into discrete chromosomes. - The nucleoli disappear - Each duplicated chromosome appears as two identical sister chromatids joined at their centromeres. - The mitotic spindle begins to form. It is composed of centrosomes and the microtubules that extend from them. The radial arrays of shorter microtubules that extend from the centrosomes are called Asters.
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