Glod_11072007 - Principles and Ethics of Clinical Research...

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Principles and Ethics of Clinical Research John Glod, M.D., Ph.D. Departments of Pediatrics and Pharmacology Robert Wood Johnson Medical School The Cancer Institute of New Jersey
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Goals of clinical research • New therapies • Improving outcomes • Reducing toxicities/side effects
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History of clinical research • Herophilos (335-280 BC) • Avicenna (980-1037) • Edward Jenner (1749-1823) • Walter Reed (1851-1902)
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Herophilos (335-280 BC) • Began to use scientific inquiry in medicine. • -used dissection • -recognized brain as center of nervous system • -described difference between arteries and veins • -described changes in the pulse with disease states
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Avicenna (980-1037) • Introduced experimentation into medicine and the idea of a clinical trial.
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Ibn Sina • TB • Diabetes
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