Sample Exam 3 - 1) Lumbar spinal degenerative disease is...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
1 1) Lumbar spinal degenerative disease is caused by mutations in the gene encoding the Vitamin D receptor. At least 40% of the normal wild-type levels of the receptor are required for normal function, while 20% - 40% of wild-type levels result in a mild form of the disease, and 0 to 20% results in severe disease. There are three alleles known for this gene: C wt (100% function), C 1 (0% function), and C 2 (30% function). a. (4 pts) What would be the genetic relationship between the C 1 and the C wt alleles (i.e. would C 1 be recessive, dominant, incomplete dominant, or codominant)? b. (4 pts) What would be the genetic relationship between the C 2 and the C wt alleles (i.e. would C 2 be recessive, dominant, incomplete dominant, or codominant to C wt )? c. (4 pts) What would be the genetic relationship between the C 1 and the C 2 alleles (i.e. would C 1 be recessive, dominant, incomplete dominant, or codominant to C 2 )? d. (4 pts) If a C wt /C 1 heterozygote had a child with a C wt /C 2 heterozygote, what would be the probability of them having a child with the severe form of the disease? 2) . A diagram of DNA being transcribed is shown below, and the template and non-template strands are indicated. a) (4 pts) Draw in the mRNA where it should be in the diagram, using an arrow to indicate the direction of transcription. b) (4 pts) Which DNA strand would the mRNA sequence be identical to (apart from the uracil)? 5’ 5’ 3’ 3’ template non-template
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 3) . The biochemical pathway shown below details the production of compound P from the precursor X from three intermediates, A, B, and C. Compounds A and B must both be used to make C. You know that 4 enzymes are necessary for the biochemical pathway and you have 4 mutants, each of which has a mutation in a gene encoding one of the enzymes. The chart below shows whether each homozygous mutant grows when supplemented with the compounds A, B, C, or P. (“-” means no growth and “+” means growth) supplements: mutant - A B C P 1 - - - + + 2 - + - + + 3 - - - - + 4 - - - + + (8 pts) Fill in the boxes in the biochemical pathway above indicating which enzyme (1, 2, 3, or 4) catalyzes which reaction. (If there is more than one possible combination, just write one). 4)
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 8

Sample Exam 3 - 1) Lumbar spinal degenerative disease is...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online