Exam 2 Fall 07 key - Name: _ EID: _ Paull Bio325 Fall 2007...

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1 Name: ________________________ EID: _____________ Paull Bio325 Fall 2007 Exam 2 10/18/07
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2 1) Dominant alleles at two loci (A and B) are required for the growth of whiskers in mice. A pure-breeding strain with no whiskers was crossed with another pure-breeding strain with no whiskers and all of their progeny had whiskers. These F 1 whiskered mice were mated with a pure-breeding strain that is homozygous recessive at both loci (aabb), and their progeny were: 19 no whiskers 1 with whiskers a. (4 pts) Based on this information, what are the genotypes of the parental mice without whiskers? b. (2 pts) What is the Chi Square value for the probability that they are linked? c. (4 pts) Are the A and B genes linked? d. (4 pts) If linked, what is the map distance between the genes? aaBB and AAbb 10 m.u. 4.27 Yes. If the genes were not linked then ~25% of the progeny would be A-B- (have whiskers) but only 5% of the progeny have whiskers
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3 2) Alport Syndrome (AS) is a rare disease that causes progressive deafness. AS and color- blindness in humans are both caused by mutations in genes on the X chromosome. AS is caused by a dominant allele while color blindness is caused by a recessive allele. A color- blind man marries a woman who has AS and normal vision. They have a daughter, Susan, who also has AS and has normal vision. If Susan has children with a normal man, and there are 0 map units between the two
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This note was uploaded on 06/19/2008 for the course BIO 325 taught by Professor Saxena during the Fall '08 term at University of Texas at Austin.

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Exam 2 Fall 07 key - Name: _ EID: _ Paull Bio325 Fall 2007...

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