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Orthomyxoviruses2 - Orthomyxoviruses Influenza A B C...

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Orthomyxoviruses Influenza A, B, C Classic “flu” Annual epidemics (mutation: drift) Periodic pandemics (reassortment: shift)
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Orthomyxoviruses Structure & Replication Genome 8 segments, negative-sense RNA Nucleoproteins Envelope Hemagglutinin (HA): binds to sialic acid, promotes fusion Neuraminidase: cleaves sialic acid, prevent clumping, promotes release Matrix, membrane proteins
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Influenza A Virus
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Influenza A Pathogenesis & Immunity Attacks mucus-secreting, ciliated, other epi cels NA cleaves sialic structures in mucus → tissue Release at apical surface of infected cells Cell-to-cell spread, promotes bacterial adhesion Pneumonia from virus or bacteria Normally, self-limiting Symptoms due to interferon Protective Abs to HA and NA Immunity strain specific
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Pathogenesis of Influenza A Infection
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Time Course of Influenza A Infection
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Influenza A Epidemiology Classification Type Place of origin Date of original isolation Antigen (HA, NA) A/Bangkok/1/79(H3N2) Zoonosis
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Reassortment in Influenza A
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