Lecture 15 2015 3x - 1 Vitamin C(Ascorbic Acid • Required...

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1 Vitamin C (Ascorbic Acid) Required by primates (including humans) and by guinea pigs Deficiency: Scurvy Loss of appetite Retarded wound healing Bleeding gums and capillaries Scurvy Corkscrew hair Periungual hemorrhage Gingival hemorrhage Pinpoint hemorrhages Vitamin C (Ascorbic Acid) Functions: Formation of collagen which is framework of bone, skin and gums Anti-oxidant Immune function Hormone and neurotransmitter synthesis
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2 Vitamin C (Ascorbic Acid) Good sources - fruit juices, fruit, spinach, asparagus RDA - 75 mg women, 90 mg men Doses above 200 mg are excreted in urine or not adsorbed in gut. Megadoses (gm quantities) cause intestinal discomfort p327
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3 Micronutrients involved in blood formation Anemia (without blood) - low blood hemoglobin • Folate Vitamin B 12 Iron (last Thursday) Folic acid Unnatural form of folate. Not found in nature Converted to reduced folate derivatives and metabolized to co-enzyme forms Folic acid is more stable than naturally occurring folates Folic acid added to food is almost twice as bioavailable as food folates
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4 Folate Coenzyme functions : Synthesis of nucleotides involved in RNA and DNA synthesis and DNA repair Amino acid metabolism including homocysteine conversion to methionine (also requires B 12 ) and methylation pathways involved in gene regulation Folate deficiency Macrocytic (megaloblastic) anemia – Caused by a severe folate deficiency – Results in fewer but enlarged red blood cells – Shows common symptoms of anemia including weakness, fatigue, difficulty concentrating, irritability, headache, shortness of breath Genesis of RBC
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