Clymer_111207 - Fluorescence Bioimaging in Translational...

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Fluorescence Fluorescence Bioimaging Bioimaging in Translational Research in Translational Research Mark Clymer Bio-Business Development Group Olympus America Inc.
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Topics Overview of fluorescence in translational research ¾ Challenges ¾ Options ¾ Opportunities Images What lies ahead?
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Fluorescence in Bioimaging Advantages ¾ Multiplexing ¾ Chemistry ¾ Resolution ¾ Speed Disadvantages ¾ Chemistry ¾ Translatability
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Bioimaging in Translational Research Fluorescence microscopy Flow cytometry High throughput screening High content screening Animal models
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Fluorescence In Vivo Introduced fluorescence ¾ Dyes and probes ¾ Transformed cells ¾ Labeled cells Inherent fluorescence ¾ Food origin ¾ Autofluorescence
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Dyes and Probes Adapted from microscopy ¾ FITC, Alexa Fluors, ICG Newer technologies ¾ Nanocrystals, Q dots Functional probes ¾ FRET pairs ¾ Protein complementation ¾ “Smart” probes
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This note was uploaded on 03/09/2008 for the course BIOS 95 taught by Professor Varies during the Spring '08 term at Lehigh University .

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Clymer_111207 - Fluorescence Bioimaging in Translational...

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