Sands_111907

Sands_111907 - Influenza, HIV, and Beyond J. A. Sands,...

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Influenza, HIV, and Beyond J. A. Sands, November 19, 2007 Lehigh University
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Electron Micrographs of Viruses A. Bacteriophage T4 B. Potato virus X C. Adenovirus D. Influenza virus What are the human pandemic potentials of these viruses?
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How do viruses reproduce? Shown here is the simplest possible virus replication cycle. Now, let’s do some math on the board.
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Influenza and HIV: What are some pandemic-related parameters? • Virus particle structure • Mechanism of transmission • Species specificity • Human immune response • Evolutionary change • Previous pandemics • Vaccines and/or antiviral drugs
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Electron Micrograph of Influenza Virus © Linda M Stannard, 1995
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Cryo-Electron Tomography of Influenza Virus Harris et al . Proc. Nat. Acad. Sci. 2006
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Copyright ©2003 by the National Academy of Sciences Lakadamyali, Melike et al. (2003) Proc. Natl. Acad. Sci. USA 100, 9280-9285 Influenza Entry into Cell
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Influenza Exit from Cell: Effect of Neuraminidase Inhibition New England Journal of Medicine, 2005
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Loo and Gale, Nature , 2007
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Sands_111907 - Influenza, HIV, and Beyond J. A. Sands,...

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