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Unformatted text preview: -Uses polystyrene beads via a CH 2 Cl group-Synthesis runs C to N terminus-Bead acts like a benzyl protecting group and can be removed in the same manner easy on easy off O C OCH 2 Ph = Cbz O C O = Boc CH 3 CH 3 CH 3 S n 2 S n 1 S n 2 S n 1 H 2 Pd/C OR HBr (anh) CF 3 COH O O C OCH 2 Ph O C O CH 3 CH 3 CH 3 Cl + base N 3 Problems: 1) Propose a synthesis for LysProMet 2) Draw the peptide GlyAspCysArg at its pI. Sketch the titration curve for this tetrapeptide. Label each half equivalance point and each equivalence point with the appropriate pH. 3) Draw a each the Fischer projection and a dash and wedge drawing of LeuTrpAsp at pH ~7 4) Starting with the bead below, propose a solid state synthesis for the oligopeptide IleProVal Cl Peptide synthesis in the lab...
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- Winter '07