Simon_09072007 - DIET AGING and MIND Neal G Simon Ph D Dept...

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DIET, AGING, and MIND Neal G. Simon, Ph. D. Dept. of Biological Sciences Lehigh University
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Outline: Diet, Aging, and Mind 1. Review 2 B i Ch i A i 2. Brain Changes in Aging 3. Dementias 4 Dietary Interventions: DHEA and Soy 4. 5. DHEA 6. Soy 7. Summary and Conclusions
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Testosterone Steroid Dehydroepiandrosterone Male Female (T) (DHEA) Active PREG S E 2 DHT T AE DHEA Metabolites Androgen Receptor GABA Target System Serotonin Vasopressin INHIBIT ENHANCE ENHANCE ENHANCE GABA A Androgen Site of 5HT 1A 5HT 1 V 1A AVP Receptor Regulated Transcription Action , 5HT 1B , AVP FACILITATION INHIBITION Effect on Aggression
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“I hope I Die Before I Get Old” Pete Townshend The WHO “My Generation” My Generation
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www youtube com/watch?v=zqfFrCUrEbY My generation The Zimmers 2:18 youtube com/watch?v=i0Xknw XqLDo&mode=related&search = The Who 37 secs
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Changes with Aging
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Brain Aging: Normal Basal Ganglia Subarachnoid Space White Matter The basal ganglia are clusters of nerve cells responsible for The subarachnoid space is the space around the outside of the The white matter is a initiatiting and integrating movements. The basal ganglia