Simon_09072007 - DIET AGING and MIND Neal G Simon Ph D Dept...

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DIET, AGING, and MIND Neal G. Simon, Ph. D. Dept. of Biological Sciences Lehigh University
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Outline: Diet, Aging, and Mind 1. Review 2 B i Ch i A i 2. Brain Changes in Aging 3. Dementias 4 Dietary Interventions: DHEA and Soy 4. 5. DHEA 6. Soy 7. Summary and Conclusions
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Testosterone Steroid Dehydroepiandrosterone Male Female (T) (DHEA) Active PREG S E 2 DHT T AE DHEA Metabolites Androgen Receptor GABA Target System Serotonin Vasopressin INHIBIT ENHANCE ENHANCE ENHANCE GABA A Androgen Site of 5HT 1A 5HT 1 V 1A AVP Receptor Regulated Transcription Action , 5HT 1B , AVP FACILITATION INHIBITION Effect on Aggression
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“I hope I Die Before I Get Old” Pete Townshend The WHO “My Generation” My Generation
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www youtube com/watch?v=zqfFrCUrEbY www.youtube.com/watch?v=zqfFrCUrEbY My generation The Zimmers 2:18 http://www youtube com/watch?v=i0Xknw http://www.youtube.com/watch?v=i0Xknw XqLDo&mode=related&search = The Who 37 secs
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Changes with Aging
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Brain Aging: Normal Basal Ganglia Subarachnoid Space White Matter The basal ganglia are clusters of nerve cells responsible for The subarachnoid space is the space around the outside of the The white matter is a initiatiting and integrating movements. The basal ganglia become bright with age due to iron accumulation. brain. This area increases in size to fill the space with age- related cell loss communication channel for the brain's information processing gray matter. White matter changes in appearance and may be related to the normal slowing of to the normal slowing of information processing in the brain with age. www.omsi.edu/visit/life/aging/brainText.cfm
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