Simon_09072007 - DIET AGING and MIND Neal G Simon Ph D Dept...

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DIET, AGING, and MIND Neal G. Simon, Ph. D. Dept. of Biological Sciences Lehigh University
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Outline: Diet, Aging, and Mind 1. Review 2. Brain Changes in Aging 3. Dementias ietary Interventions: DHEA and Soy 4. Dietary Interventions: DHEA and Soy 5. DHEA . Soy 6. Soy 7. Summary and Conclusions
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estosterone teroid ehydroepiandrosterone Male Female Testosterone Steroid Dehydroepiandrosterone (T) (DHEA) Active PREG S E 2 DHT T AE DHEA Metabolites Androgen Receptor GABA Target System Serotonin Vasopressin INHIBIT ENHANCE ENHANCE ENHANCE GABA Androgen Site of HT 5HT VP A Receptor Regulated Transcription Action 5HT 1A , 5HT 1B V 1A , AVP FACILITATION INHIBITION Effect on Aggression
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“I hope I Die Before I Get Old” Pete Townshend The WHO “My Generation” My Generation
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ww youtube com/watch?v=zqfFrCUrEbY www.youtube.com/watch?v=zqfFrCUrEbY My generation The Zimmers 2:18 ttp://www youtube com/watch?v=i0Xknw http://www.youtube.com/watch?v=i0Xknw XqLDo&mode=related&search = The Who 7 secs 37 secs
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hanges with Aging Changes with Aging
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Brain Aging: Normal Basal Ganglia Subarachnoid Space White Matter The basal ganglia are clusters of nerve cells responsible for The subarachnoid space is the space around the outside of the The white matter is a initiatiting and integrating movements. The basal ganglia become bright with age due to iron accumulation. brain. This area increases in size to fill the space with age- related cell loss communication channel for the brain's information processing gray matter. White matter changes in appearance and may be related the normal slowing of to the normal slowing of information processing in the brain with age. www.omsi.edu/visit/life/aging/brainText.cfm
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Brain Aging: Normal he ippocampus the memory he entricles re hollow spaces The hippocampus is the memory center of the brain. There is some cell loss associated with healthy aging, but this by itself does not indicate significant memory loss. The ventricles are hollow spaces filled with cerebrospinal fluid. Like the subarachnoid space, these spaces increase in size as the brain becomes smaller with age. www.omsi.edu/visit/life/aging/brainText.cfm
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ocial Cost of Dementias: $100 Billion/Year Social Cost of Dementias: $100 Billion/Year ¾ significantly impaired intellectual functioning that interferes with normal activities and relationships. ¾ Inability to solve problems and maintain emotional control ¾ Experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations. ¾ Memory loss is a common symptom of dementia ¾ Doctors diagnose dementia only if two or more brain functions - such as memory and language skills -- are significantly impaired without loss of consciousness. lzheimer’s disease vascular dementia Lewy body dementia frontotemporal Alzheimer s disease, vascular dementia, Lewy body dementia, frontotemporal dementia, Huntington’s disease, and Creutzfeldt-Jakob disease
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Alzheimer’s Disease emory loss ¾ Memory loss ¾ Language deterioration ¾
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Simon_09072007 - DIET AGING and MIND Neal G Simon Ph D Dept...

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