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Simon_090507 - Neurobiology of Aggression and Violence gy...

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Neurobiology of Aggression and Violence: Systems, Intervention, and Impact Neal G. Simon, Ph. D. Professor Dept. of Biological Sciences Lehigh University
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Outline: Goals 1 O i 1. Overview 2. Regulatory Systems a. hormones b. neurotransmitters c. interactions 3. Intervention and Imaging 4. Aggression as a Model for Disease a. stress-related affective illness 5. Aging and Diet a. supplements b impact on aggression and imp lsi it b. impact on aggression and impulsivity c. neurogenomics 6. Summary and Conclusions
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Genetics: One Gene Models Witkin et al (1976). Criminality in XYY and XXY men. Science Saudou et al (1994). Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science Nelson, et al. (1995) Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature Brunner et al. (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science O (1997) B h i l ff t f t t di ti i l i PNAS Ogawa (1997). Behavioral effects of estrogen receptor gene disruption in male mice. Merriman, Cameron (2007). Risk-taking: behind the warrior gene story. NZ Medical Journal Complex Social Behaviors Integrate Multiple Gene Pathways: Neurogenomics
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Economic Burden Violent Offenses: $70 billion Stress-Related Affective Illness: $125 billion Dementias $100 billion TOTAL $295 billion Biological Sciences
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