Simon_090507

Simon_090507 - Neurobiology of Aggression and Violence: gy...

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Neurobiology of Aggression and Violence: Systems, Intervention, and Impact Neal G. Simon, Ph. D. rofessor Professor Dept. of Biological Sciences Lehigh University
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Outline: Goals 1. Overview 2. Regulatory Systems a. hormones b. neurotransmitters c. interactions . Intervention and Imaging 3. Intervention and Imaging 4. Aggression as a Model for Disease a. stress-related affective illness 5. Aging and Diet a. supplements impact on aggression and imp lsi it b. impact on aggression and impulsivity c. neurogenomics 6. Summary and Conclusions
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Genetics: One Gene Models Witkin et al (1976). Criminality in XYY and XXY men. Science Saudou et al (1994). Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science Nelson, et al. (1995) Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature Brunner et al. (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science Ogawa (1997). Behavioral effects of estrogen receptor gene disruption in male mice. PNAS Merriman, Cameron (2007). Risk-taking: behind the warrior gene story. NZ Medical Journal Complex Social Behaviors Integrate Multiple Gene Pathways: Neurogenomics
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Economic Burden Violent Offenses: $70 billion Stress-Related Affective Illness: $125 billion Dementias $100 billion TOTAL $295 billion Biological Sciences
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Aggression and Violence: A Systems Perspective BEHAVIOR, LIFE EVENTS, & ENVIRONMENT CIRCUITS CELLS ADAPTATION MOLECULES GENES Biological Sciences
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Definitions ¾ Conspecific Aggression art of reproduction Part of reproduction Establishment of dominance status Access to Resources ¾ Violence/Inappropriate Aggression Intent to harm and cause injury ssault murder Assault, murder
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Sex Differences Male Facilitation T and Metabolites emale hibition DHEA Female Inhibition Biological Sciences
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Target Systems H O CH 3 CH 3 O 5-HT AVP OH TESTOSTERONE OH GABA DHEA ESTRADIOL
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estosterone teroid ehydroepiandrosterone Male Female Testosterone Steroid Dehydroepiandrosterone
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Simon_090507 - Neurobiology of Aggression and Violence: gy...

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