Cassimeris_92107 - Cell Division the Cell Cycle 1x 14 10...

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Cell Division & the Cell Cycle
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1 10 14 1 x 10
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684 931 684,931
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1
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Cell divisions in your body -every cell from a cell- B t ll Bone marrow stem cells >1,000,000 divisions per minute Ski t ll Skin stem cells Intestinal stem cells Muscle satellite cells Liver cells
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Cancer = excess cell division Figure 13.17. Cells. Jones and Bartlett Publishers.
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Cell Division Cycle
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Mitosis Overview
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( i f i i h h ) (a movie of mitosis was shown here)
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Mitosis-blocking drugs are used to treat cancers
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The Key Parts: Kinetochore microtubule Pole or centrosome
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How do chromosomes make correct attachments when mitosis begins?
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Microtubules find things (a movie of microtubule assembly & disassembly was shown here)
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Search & Capture
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The right connections Form attachments Check tt h t Divide attachments
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Mitotic Errors are Deadly Normal mitosis Equal genome division Abnormal mitosis Unequal genome Unequal genome division
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Error Correction error new capture Release wrong tt h t Tension = t attachment correct
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Kinetochore proteins sense tension
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Errors are detected & fixed Correct attachments Activate checkpoint checkpoint, “WAIT” & correct
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When all goes well……
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