LoweKrentz_092407 - Cancer and Oncogenes Bioscience in the...

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Cancer and Oncogenes Bioscience in the 21 st Century Linda Lowe-Krentz
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Just a Few Numbers • Becoming Cancer Becoming Cancer Genetic Defects • Drugs
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Our friends and family 140 160 180 Exposure to carcinogens 80 100 120 Incidence of Times that cells divide 20 40 60 Incidence of cancer More than one mutation 0 to 5 to 15 to 30 to 45 to 60 to 75 to 90 15 30 45 60 75 90
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Required characteristics ¾ Original hypothesis – 2 mutations one in Original hypothesis 2 mutations, one in signaling and one in the nucleus. ¾ Statistical analysis says more like 5 Statistical analysis says more like 5 mutations probably contribute to cancer. ¾ T i ll l i i i Typically at least one mutation is in a proliferation pathway. ¾ Benign cancer requires at least one additional mutation.
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Evolution of a cancer cell
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Abilities acquired ¾ Grow rapidly ¾ Dissociate from neighboring cells ¾ Invade adjacent tissue ¾ Invade blood vessels or lymphatic system ¾ E i t Escape immune system ¾ Arrest in a new location ¾ Get into target tissue ¾ Proliferate in new location
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Normal Dysplasia Pre-malignant, appear abnormal
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