LoweKrentz_092407

LoweKrentz_092407 - Cancer and Oncogenes Bioscience in the...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Cancer and Oncogenes Bioscience in the 21 st Century Linda Lowe-Krentz
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
• Just a Few Numbers ecoming Cancer • Becoming Cancer • Genetic Defects • Drugs
Background image of page 2
Our friends and family 40 160 180 • Exposure to carcinogens 0 100 120 140 cidence of • Times that cells divide 0 40 60 80 Incidence of cancer • More than one mutation 0 20 to to 5 to 0 to 5 to 0 to 5 to 0 5 15 30 45 60 75 90
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
equired characteristics Required characteristics riginal hypothesis mutations one in ¾ Original hypothesis 2 mutations, one in signaling and one in the nucleus. tatistical analysis says more like 5 ¾ Statistical analysis says more like 5 mutations probably contribute to cancer. ¾ Typically at least one mutation is in a proliferation pathway. ¾ Benign cancer requires at least one additional mutation.
Background image of page 4
volution of a cancer cell Evolution of a cancer cell
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
bilities acquired Abilities acquired ¾ Grow rapidly ¾ Dissociate from neighboring cells vade adjacent tissue ¾ Invade adjacent tissue ¾ Invade blood vessels or lymphatic system
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 22

LoweKrentz_092407 - Cancer and Oncogenes Bioscience in the...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online