Lecture 30 DNA Replication slides

Lecture 30 DNA Replication slides - DNA Replication and...

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DNA Replication and Repair Chapter 16 6 th ed: pp. 293-301 7 th ed: pp. 299-307 To learn well: Sum of DNA replication (Fig. 16.16, 7th ed.)
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s model for DNA replication 1. Complementary DNA strands temporarily separate Weak hydrogen bonds between bases are easy to break.
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2. New nucleotides are inserted in turn, following base-pairing rules, using BOTH original strands as templates.
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3. Nucleotides are con- nected to make new continuous strands Replication is semi- conservative ; each new molecule has 1 old, and 1 new strand.
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General name for any nucleotide: dNTP Each sugar C has a number (1’-5’) 5’C: linked to phosphate 3’C: linked to free OH 1’ 4’ 2’
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Step 1. Correct dNTP base pairs with a base in template
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Step 2. Phosphate of incoming dNTP is linked to -OH on the last sugar of the new strand sugar phos- phate
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Pyrophosphate (P-P) is released when the new phosphodiester bond is made.
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BOTH checks that base pairing is correct, and forms the bond to link the new nucleotide to the end of the strand. DNA polymerase
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Lecture 30 DNA Replication slides - DNA Replication and...

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