Lecture 42 Devel Mechs_2TO POST slides

Lecture 42 Devel Mechs_2TO POST slides - I. Pattern...

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I. Pattern Formation (Drosophila) II. Differentiation 6th ed: 406-418 7th ed: 412-425; 431-432
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Example in animals: gastrulation. Problem: little is known about molecular details of how this works in Lots is known about pattern formation in Drosophila . Some proteins & principles are turning out to be the same in humans. Pattern formation: setting up basic develop in the right place. Plan is established before the structures themselves develop.
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Drosophila develoment 1. Fertilized egg de- velops into embryo
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2. Embryo hatches into larva (no gastrulation!)
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3.Larva metamorph- oses into adult.
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bicoid mRNA (a cytoplasmic determinant) is stored in egg; concentrated at anterior end. Early event in pattern formation: setting up anterior-posterior axis (which end is the head).
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After fertilization, the mRNA is translated into Bicoid protein in the embryo. Bicoid protein in early embryo. Bicoid protein gradient sets up the A-P axis!
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Mutation of bicoid that destroys its function gives embryo with two back ends; no front end.
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Embryonic lethal: mutation that gives defective protein. As a result, organism dies early in development. Defects in dead embryo can give information on normal function of gene. Bicoid protein : a transcription factor. It stimulates expression of certain genes.
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Segments : basic units of pattern formation in adult. Adult structures develop from segments in the larva.
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expression of genes
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This note was uploaded on 06/25/2008 for the course BIO 202 taught by Professor Dean during the Fall '08 term at SUNY Stony Brook.

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Lecture 42 Devel Mechs_2TO POST slides - I. Pattern...

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