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IMMUNE SYSTEM REVIEW ACTIVITY NEUTROPHILS Most abundant of the white blood cells, 60-70% Phagocyte, is capable of digesting organisms. They have sacs filled with digestive enzymes that burst and break down the organism. Part of the non-specific immune response Antigen presenting cell-when the bacteria or virus is digested a piece of it is packaged in the golgi apparatus and placed on the surface of the cell. A CD4 cell picks up the piece so it can be recognized. LYMPHOCYTES There are two main types-T Cells and B Cells-40% of WBC T Cells-Chemically destroy enemy, “T” stands for thymus Cytoxic T Cells-CD8-These are killers and destroy a specific enemy Helper T Cells-CD4-Secrete cytokines, which sends a signal for an immune response, communicate between specific and non-specific immunity Suppressor T Cells-suppress immune response Nk Cells-Natural killer-attacks tumors, is helped by B Cells Lymphocytes B cells-2 types "B" stands for the bursa of Fabricius Plasma B Cells-Secrete antibodies, which chemically bind to antigens and opsonize them. Memory B Cells-Formed for specific antigens, live for long periods of time, and can quickly respond to an invader the second time it invades MONOCYTES Phagocyte-about 8% of WBC Ingests antigens Monocytes can stay in one area or system or move around the body Alveolar Macrophages-monocytes in lungs Kupffer Cells-monocytes in liver Microglial Cells-monocytes in nervous system EOSINOPHILS Phagocyte-granulocyte- about 1% of WBC Responsible for attacking and destroying worms and parasites in the body. BASOPHILS Least common WBC-less than 1% Closely associated with mast cells and the allergic response Secretes histamine, proteoglycans, leukotrienes, and cytokines.
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All contributes to inflammation COMPLEMENT CASCADE Classic Triggered by C1 complex Relies on Pathogen binding protein Triggers a several proteins to bind together Alternative Triggered by C3 hydrolysis Does not rely on pathogen binding protein
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