Lymphoma v Leukemia

Lymphoma v Leukemia - Describe the differences between a...

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Describe the differences between a Lymphoma and Leukemia. The lymphoid neoplasms encompass a group of entities that vary widely in their clinical presentation and behavior. As tumors of the immune system, lymphoid neoplasms often disrupt normal immune regulatory mechanisms. These neoplasms can either be characterized as lymphomas or leukemias. Leukemias are tumors that primarily involve the bone marrow with spillage of neoplastic cells into the peripheral blood. Lymphomas are tumors that produce masses in involved lymph nodes or other tissues. All lymphoid systems have the potential to spread to lymph nodes and various tissues throughout the body, especially the liver, spleen, and bone marrow. Lymphomas can spill over into the peripheral blood, creating a leukemia-like picture. Conversely, leukemias of lymphoid cells, originating in the bone marrow, can infiltrate lymph nodes and other tissues, creating a histologic picture of lymphoma. The various lymphoid neoplasms can only be distinguished based on the appearance and molecular characteristics of the tumor cells, not on the location within patients’ bodies. There are two recognized lymphomas: Hodgkin and Non-Hodgkin lymphomas. In the United States, there has been a general decline in HD rates over the past 20 years, so that this disease now accounts for only 1% of all cancers. By contrast, non-Hodgkin's lymphoma has increased by more than 70% during this period and now represents 4% of all American cancers. It is the fifth most common malignancy in this country. Hodgkin Lymphomas: Hodgkin's lymphoma is characterized clinically by the orderly spread of disease from one lymph node group to another and by the development of systemic symptoms with advanced disease. Pathologically, the disease is characterized by the presence of Reed-Sternberg cells. The cure rate is about 93%, making it one of the most curable forms of cancer. Unlike some other lymphomas, whose incidence increases with age, Hodgkin's
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This note was uploaded on 06/26/2008 for the course BIO 1101 taught by Professor Don'tremember during the Spring '08 term at FSU.

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Lymphoma v Leukemia - Describe the differences between a...

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