2.+Blood_presentation - Blood What is the study of blood?...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
Blood What is the study of blood?
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What is blood? Accounts for 8% of body weight Female 4-5 of blood Male 5-6 L of blood DISTRIBUTION Supplies O2 from lungs to cells Supplies nutrients from GI tract to cells Transports metabolic wastes from cells Transports hormones to target tissues/organs REGULATION Regulates body temperature Regulates the pH of body fluids Regulates blood volume to support efficient circulation PROTECTION Prevents blood loss Prevents infection through the activity of white blood cells, complement & antibodies
Background image of page 2
Plasma Liquid part of blood Contains Water Hormones/Enzymes Nutrients Electrolytes Respiratory Gases Wastes Albumin - 60% Globulins - 36% Clotting Proteins - 4% - Proteins Produced where?
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Serum Albumin - 60% Globulins - 36% Clotting Proteins -4% Plasma Serum X Clot
Background image of page 4
Hematocrit Percent of formed elements Hematocrit Normal Hematocrit - 45% depending on gender
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Formed Elements - Cells/Components Erythrocytes (RBCs) M 4.6-6.2 mil/mm3 F 4.2-5.4 mil/mm3 Leucocytes (WBCs) 5,000-10,000/mm3 Platelets 130,000-400,000/mm3 Why ?
Background image of page 6
Properties of blood Viscosity - resistance to flow Determined by? Osmolarity - total molarity of dissolved particles Determined by? What if it is too high? What if it is too low? Colloid osmotic pressure
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Erythrocytes (RBCs) Disc-shaped cell with thick rim Lack nucleus/little organelles Small size and biconcave shape Lack mitochondria and generate ATP by anaerobic mechanisms Major function gas transport 33% of cytoplasm is hemoglobin (Hb) Major contributors to blood viscosity
Background image of page 8
Hypotonic Low solutes High water Isotonic 0.9% saline 5% glucose Hypertonic High solutes Low water Swollen Crenated
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Hemoglobin A Structure Heme group – bound to each protein chain Inds O2 to ferrous ion Fe+2 to form Oxyhemoglobin Deoxyhemoglobin - reduced hemoglobin O2 detaches from Hb Carbaminohemoglobin CO2 (20%) bound to globin Globin 25% HbA2 HbAIC HbF in fetus
Background image of page 10
Hematopoiesis / Hemopoiesis To make blood Erythropoiesis/Leucopoiesis/Thrombopoiesis In adults occurs in the red bone marrow from a stem cell - hemocytoblast considered a pluripotential cell b/c it is a source of all formed elements and differentiates into progenitor cells Can occur in liver or spleen in diseases in which bone marrow is destroyed Red vs. Yellow marrow?
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Erythropoiesis (3-5 days) Proerythroblast First committed cell - receptors for erythropoietin from kidneys, liver Erythroblast Normoblast Hb accumulation and ejection of nucleus Reticulocyte ( young red blood cell ) network of endoplasmic reticulum and ribosomes enters bloodstream as 0.5 to 1.5% of circulating RBCs
Background image of page 12
Erythrocyte Homeostasis Negative feedback control drop in RBC count causes hypoxemia to kidneys EPO production stimulation of bone marrow
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 14
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 06/28/2008 for the course HLTH 2532 taught by Professor Sturges during the Spring '08 term at Georgia Southern University .

Page1 / 46

2.+Blood_presentation - Blood What is the study of blood?...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online