Immunity_notes - Overview of the immune system Two...

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Overview of the immune system Two intrinsic defense systems that work independently and cooperatively 1. Innate (nonspecific) defense 1st line of defense: the external body membranes 2nd line of defense: antimicrobial proteins, inflammation, fever, phagocytes, NK inflammation is the most important mechanism 2. Acquired (specific) defense 3rd line of defense: attacks specific pathogens ** “lines of defense” are not as linear as they appear
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Active immunity leaves us WITH MEMORY Passive immunity leaves us WITHOUT MEMORY Acquired Immunity
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Major Histocompatibility Complex MHC proteins are a self-antigen found on all nucleated cells A marker that allows us to recognize the cell as self and will (should) not trigger an immune response A groove “hotdog bun” that displays a peptide MHC 1 vs. MHC 2
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Antigens Substances, such as bacteria, viruses etc. , that can mobilize the immune system and provoke an immune response These substances are recognized as “non-self” Complete antigens vs. incomplete antigens Epitopes stimulate immune response
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Antigens Characteristics of complete antigens Immunogenicity - ability to stimulate proliferation of specific lymphocytes and antibodies Reactivity - ability to react with products of immunogenicity (lymphocytes and antibodies) Characteristics of incomplete antigens No immunogenicity Have reactivity Penicillin, poison ivy, detergents, cosmetics
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Aspects of the adaptive immune response Important We must be introduced to each specific foreign substance to develop our defense Characteristics of the adaptive immune response is antigen-specific is systemic has memory Humoral immunity = antibodies produced by B-cells Cell-mediated immunity = T-cells themselves defend the body
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A couple of notes on lymphocytes…. . Both branches act in four stages
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This note was uploaded on 06/28/2008 for the course KINS 2532 taught by Professor Sturges during the Spring '08 term at Georgia Southern University .

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Immunity_notes - Overview of the immune system Two...

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