quizzes_Quiz_8_CHEM239Bspr06

quizzes_Quiz_8_CHEM239Bspr06 - Bradykinin...

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Chem 239B Spring, 2006 Quiz#8 Prof. Sasaki _____________________________________________________________________ 1. The imidazole ring of the histidine side chain acts as a proton acceptor in certain enzyme-catalyzed reactions. Which is the more stable protonated form of the histidine residue, A or B? Why? HN NH NH O N N NH O H H B A + + 2. How many peaks would you expect to see on the strip chart after amino acid analysis of bradykinin and its analogue? Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
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Unformatted text preview: Bradykinin Arg-Pro-Pro-Gln-Pro-Glu-Pro-Gln-Arg Bradykinin analogue 3. (a) The nucleoside vidarabine (ara-A) shows promise as an antiviral agent. Its structure is identical to that of adenosine except that D-arabinose replaces D-ribose as the carbohydrate component. Write a structural formula for this substance. (b) The compound 2',3'-dideoxyinosine (DDI) holds promise as a drug for the treatment of AIDS. What is the structure of DDI? O N N N NH O HO HO OH inosine...
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This note was uploaded on 06/30/2008 for the course CHEM 239 taught by Professor Sasaki during the Spring '06 term at University of Washington.

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