Lecture 20 - Final Review

Lecture 20 - Final Review - Regulation by Non-coding RNA:...

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active in gene control in eukaryotes except yeast allows specific “zip code” recognition) - likely evolved as cell defense against RNA virus infections (note:  anti-viral cytokine, interferon- β , now shown to induce cellular anti-viral miRNAs)  Role in controlling many key processes in eukaryotic organisms now well established (e.g., development,  genomes)  Multiple mechanisms of RNAi control (e.g., inhibition of translation, mRNA degradation, gene silencing  Some known regulatory non-coding RNA are large transcripts (Xist =       10,000 nt), but most are small (21-25 bp long) single-stranded RNAs called microRNAs (miRNA interfering RNAs (siRNA ) that are processed from double-stranded RNAs by Dicer enzymes:
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Lecture 20 - Final Review - Regulation by Non-coding RNA:...

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