Lecture2

Lecture2 - Protein structure 1. Amino acids 2. Protein...

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Unformatted text preview: Protein structure 1. Amino acids 2. Protein structure peptide bond, primary, secondary, tertiary, quaternary structure domain 3. Protein folding & modification Protein Proteins are polypeptides made up of amino acids There are 20 different amino acids , each with different chemical properties The 3D shape a protein adopts is determined by its sequence of amino acids The large number of 3D shapes that proteins can assume allows them to perform a wide range of functions Basic Structure of Amino Acids Glycine - smallest side group Cysteine - forms disulfide bonds (covalent bond) Proline - the only cyclic amino acid. Often involved in bends in protein chains. Peptide bonds The covalent bond between two adjacent amino acids in a peptide is called peptide bond. 6N HCl breaks peptide bonds and hydrolyzes polypeptides The peptide bond is formed by joining the amino end of one amino acid to the carboxyl end of another amino acid. .. protein sequence comparison G LS DG E WQL V LN V W GKV E A DIPGH G QE V L I R L F KGH P ETLEKF G LS DG E WQL V LN V W GKV E A DLAGH G QD V L I R L F KGH P ETLEKF E LS EA E RKA V QA M W ARL Y A NCEDV G VA I L V R F F VNF P S----- D.M. H.M. H.H D.M. Dolphin myoglobin, H.M. human myoglobin, H.H. human hemoglobin Protein homology : means either identical amino acid or similar amino acid. This is because change of an amino acid in a protein to a different amino acid with similar chemical property usually cause no harm to the protein with respect to its function. Similar amino acids:- acidic: E, D- basic: K, R, (H),- polar uncharged: S, T, N, Q, C, (H), (Y)- hydrophobic: L, I, A, V, G, M, F, P, W, (Y)- some are less sure than others (e.g. Y, H). Protein structure The structure of a protein can be divided into several levels: Primary Secondary Tertiary Quarternary Primary (1 o ) structure- linear amino acids sequences (also called protein sequences) e.g....
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This note was uploaded on 07/02/2008 for the course LS 3 taught by Professor Lin during the Spring '06 term at UCLA.

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Lecture2 - Protein structure 1. Amino acids 2. Protein...

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