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notes 2 - Notes for mRNA synthesis in eukaryotes Overview...

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Notes for 10/24/07 mRNA synthesis in eukaryotes Overview: Eukaryotes have three different RNA polymerases, each of which transcribes specific types of genes. RNA polymerase II transcribes protein coding genes, whereas RNA polymerases I and III are responsible for transcribing genes that encode structural RNAs, for example, rRNA, tRNA, and snRNA. In class, we will focus on genes transcribed by RNA polymerase II. The initial RNA polymerase II transcript is a precursor (pre-mRNA) that undergoes several processing/modification reactions to produce the mature mRNA. A 7-methyl guanosine cap is added to the 5’ end, a poly(A) tail is added to the 3’ end, and introns are removed by splicing. During class, we will discuss what happens during each of these reactions. Splicing and polyadenylation involve the recognition of particular sequences in the pre-mRNA by specific protein or snRNP complexes. These reactions are complicated, and, thus, you will not be expected
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