notes 5

notes 5 - Notes for 10/31/07 Translation The ribosome then...

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Notes for 10/31/07 Translation The ribosome then translocates 3 bases along the RNA. ??? says the summary but the textbook says the ribosome moves along one base Overview: Translation can be divided into three steps: initiation, elongation and termination. The processes are very similar in prokaryotes and eukaryotes. The mRNA is translated in the 5’ to 3’ direction. The amino or N-terminal end of the protein is encoded by the 5’ region of the mRNA and the carboxy or C-terminal end is encoded by the 3’ region. In prokaryotes, a ribosome binding site or Shine-Dalgarno sequence is located in the 5’ leader region a short distance upstream of the start codon. The first step in initiation is binding of the small ribosome subunit to this sequence. Then the initator tRNA binds. The final step in initiation is binding of the large ribosomal subunit. In eukaryotic initiation, first an initiation factor binds to the 5’ cap of the mRNA. Then small subunit of the eukaryotic ribosome, initiator tRNA and other factors are thought to bind and scan
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This note was uploaded on 07/02/2008 for the course BIOL 202 taught by Professor Kieber-hogan during the Fall '08 term at UNC.

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notes 5 - Notes for 10/31/07 Translation The ribosome then...

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