MBIO 3410 lecture Sept 6 2007

MBIO 3410 lecture Sept 6 2007 - Molecular Biology (MBIO...

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1 Molecular Biology (MBIO 3410) 2007 Instructor: Dr. Jason Richardson Lectures: Fall TR 10:00-11:15 200 Armes Text: Analysis of Genes and Genomes, R. Reece Topics: Structure, organization and expression of genes in prokaryotes and eukaryotes. Principles of gene manipulation technology. Marking: Midterm exam (40%), Final exam (60%)(TBA).
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2 OUTLINE Fundamental understanding of the central dogma of Fundamental understanding of the central dogma of molecular biology molecular biology Variations on the central dogma theme (some examples) Variations on the central dogma theme (some examples) Retro-viruses Single stranded RNA phages Selfish DNA DNA type “mobile” elements “Self-replicating” systems Infectious proteins
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3 Fundamental understanding of the central dogma of molecular biology: Fundamental understanding of the central dogma of molecular biology: Copyright 1999 Access Excellence @ the National Health Museum Transcription of DNA to RNA to protein : This dogma forms the backbone of molecular biology and is represented by four major stages: The DNA replicates its information in a process that involves many enzymes = replication The DNA codes for the production of messenger RNA (mRNA) during transcription In eukaryotic cells, the mRNA is processed (essentially by splicing) and migrates from the nucleus to the cytoplasm Messenger RNA carries coded information to ribosomes. The ribosomes "read" this information and use it for protein synthesis. This process is called translation Proteins do not code for the production of protein, RNA or DNA. They are involved in almost all biological activities, structural or enzymatic
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4 *Retro-viruses RNA (infectious nucleic acid encapsulated) translated to protein (reverse transcriptase)
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MBIO 3410 lecture Sept 6 2007 - Molecular Biology (MBIO...

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