MBIO 3410 lecture Sept 11 2007

MBIO 3410 lecture Sept 11 2007 - OUTLINE last lecture...

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1 OUTLINE – last lecture Fundamental understanding of the central dogma of molecular biology Variations on the central dogma theme (some examples) Retro-viruses Single stranded RNA phages Selfish DNA DNA type “mobile” elements “Self-replicating” systems Infectious proteins Genomes and Genes Human genome Nucleic acid is the material of heredity
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2 Nucleic Acids (DNA & RNA): Made up of linear chains of molecules called nucleotides Nucleotides contain: Nitrogenous base 5 carbon sugar Phosphate group Base + sugar = nucleoside
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3 Bases Purines Pyrimidines
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4 Nucleosides Base covalently bonded to the 1’-position of: Ribose (RNA) 2’-Deoxyribose (DNA) Bond = glycosylic bond R=OH:cytidine R=H:deoxycytidine
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5 Nucleotides Nucleotide = nucleoside + one or more phosphate groups
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7 Question? What is this? Answer… dGDP What is the difference dGDP and GDP?
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8 Fig 1.6 DNA polymerase Nucleic acid polymers = ribose or deoxyribose linked by phosphate between the 5’-position of the sugar and the 3’-position of the next 3’,5’-phosphodiester bond Nucleic acids = -ve charge (phosphate) Phosphodiester bonds
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9 Chargaff’s Rules A = T and G = C Sum of the purines = sum of the pyrimidines The % of (G + C) does not necessarily = the % of (A + T) www.mun.ca www.copernicusproject.ucr.edu
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10 The DNA double helix: 2 separate antiparallel polynucleotide chains coiled around a central axis (right handed) Bases are stacked inside the helix 0.34
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MBIO 3410 lecture Sept 11 2007 - OUTLINE last lecture...

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