Patho - Gould Chapters 17 and 18

Patho - Gould Chapters 17 and 18 - Gould Chapters 17...

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Unformatted text preview: Gould Chapters 17 & 18 Blood and Lymphatic Disorders Blood critical part of bodys defenses, carries antibodies and WBCs. Also helps control body temperature. Clotting factors in blood are readily available for hemostasis, and helps maintain a stable pH of 7.35-7.45. Adult body has about 5L of blood. Hematocrit- proportion of cells (i.e. erythrocytes) in blood and indicates viscosity. If its elevated, that could mean dehydration or excess red blood cells. Low could result from blood loss or anemia. Plasma- clear yellowish fluid remaining after cells have been removed Serum- fluid and solutes remaining after the cells and fibrinogen have been removed Plasma proteins- albumin (maintains osmotic pressure), globulines (antibodies), and fibrinogen (forms blood clots). Red bone marrow- found in flat and irregular bones. Iliac crest in pelvic bone is common spot for bone marrow aspiration for biopsy. Erythropoietin- originates in kidney and stimulates erythrocyte production in red bone marrow in response to tissue hypoxia (insufficient oxygen for cells). Hemoglobin- globin portion, two pairs of amino acid chains, and four heme groups (each containing a ferrous iron atom), to which the oxygen molecule can attach. Heme provides red color. Hemoglobin becomes fully saturated with oxygen in the lungs Oxyhemoglobin- bright red in color, distinguishing arterial blood from venous blood, as blood circulates through body, oxygen dissociates Deoxyhemoglobin- dark or bluish-red in color and is found in venous blood Carbon monoxide poisoning can be easily recognized by the bright cherry-red color in the lips and face. RBCs only last about 120 days. Excess iron can b stored as ferritin or hemosiderin in the liver, blood, and other body tissues. Hemochromatosis, a genetic disorder, results in large amounts of hemosiderin accumulating, causing serious damage. Excessive hemolysis can cause elevated serum bilirubin levels, which results in jaundice, yellow color in sclera of the eye and of skin. WBCs leave capillaries and enter tissues by diapedesis (movement through an intact capillary wall) when they are needed for defensive purposes. capillary wall) when they are needed for defensive purposes....
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This note was uploaded on 07/08/2008 for the course PSB 329 taught by Professor Ally during the Spring '07 term at MCPHS.

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Patho - Gould Chapters 17 and 18 - Gould Chapters 17...

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