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talk cogsci paper

talk cogsci paper - connections of the visual system...

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Lina Dajani A07132181 Speaker-Lisa Boulanger In her talk, Professor Boulanger explained her research with the major histocompatibility complex (MHC) class I, and its participation in brain development. MHC class I, she explained, are a group of proteins that “allow T cells to recognize and destroy infected cells.” Although we thought that these immune cells are indiscernible by neurons, we now know that we were mistaken. Not only are these cells recognized by the neurons, but they play very important roles in the brain. MHC help to develop adult circuits and synaptic plasticity. These proteins affect long term potentiation and long- term depression in the hippocampus. In addition, they have proven to affect the
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Unformatted text preview: connections of the visual system. However, Boulanger explains that there is much more roles played by these proteins of which we still have no knowledge of. Another implication that is being explored with MHC class I are the nuerodegenrative disorders. Autism, specifically, could have a link with the immune system. Mouse models are currently being tested for MHC class I in the brain during development. In addition, Parkinson’s disease peculiarly demonstrates high levels of MHC class I in the substantia nigra. Therefore, by exploring if MHC class I’s intensity could affect development of the brain, we could affect treatment of different disorders....
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