classes_summer07_153A-2ID18_Midterm_II_S07_Key

classes_summer07_153A-2ID18_Midterm_II_S07_Key - Name ID...

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Name : __________Key________ ID # : _____________________ Signature : _____________________ Summer 2007 Midterm II (100 pt, 50 min) 1
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1) Hemoglobin (30 pt) a) Carbon dioxide can react covalently with a specific portion of hemoglobin to regulate the transition between T and R states. Draw an electron pushing mechanism to show this modification. Hints: you will need one carbon dioxide molecule and the relevant functional group of the hemoglobin subunit. (8 pt) x N H H C O O X N C H O O + H + b) Where does this modification typically happen? Tissues or the lungs? (1 pt) Tissue c) What is the transition of the hemoglobin state at the tissues? R T or T R? (2 pt) R T d) If the pH in the tissues increased relative to the normal condition of pH 7.4, would this favor the transition described in part c? Briefly explain. (4 pt) No Lower pH favors protonation of functional groups and R T transition or Higher pH favors deprotonation of functional groups and T R transition e) Sketch out a typical hemoglobin binding curve (fractional saturation vs oxygen partial pressure) at average physiological pH of 7.4 (P50 = 5; 99% saturated at PO 2 = 15 kPa). Number and label the axes appropriately including units. (9 pt) f) If the pH increases above 7.4, does this increase or decrease oxygen binding compared to the normal pH of 7.4? Illustrate and label this change in the curve in part e. (6 pt) 2
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This note was uploaded on 07/09/2008 for the course BIO CHEM 153A taught by Professor Staff during the Summer '06 term at UCLA.

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classes_summer07_153A-2ID18_Midterm_II_S07_Key - Name ID...

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