8.1 - Module 8 Complex Inheritance George Mellick E-mail [email protected] Telephone 3735 5019(Room N44 2.11 References Chapter 22 of

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Module 8 Complex Inheritance George Mellick E-mail [email protected] Telephone 3735 5019 (Room N44 2.11) • References – Chapter 22 of Pierce “ Genetics – A conceptual approach”
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• Types of traits • Genes and quantitative traits • Introduction to statistical methods for analysing quantitative traits • Phenotypic variance • Heritability/types of heritability • Mapping QTLs • Response to selection • Limitations of quantitative trait genetics Complex Inheritance
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Discontinuous traits – traits with only a few possible phenotypes that fall into discrete classes – phenotype is controlled by one or only a few genes Types of traits
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Types of traits Continuous traits / Quantitative traits – Do not fall into discrete classes – Populations show a distribution of phenotypes – Described by quantitative measurements – Controlled by multiple genes (polygenic) and affected by the environment to varying degrees Crop yield Fat content of meat Blood Pressure Learning Ability Expression of TNF-alpha in blood Milk production in cows Striatal dopaminergic activity (Med. Gen. lecture)
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Types of traits Meristic (countable) characteristics – Have a limited number of possible values • Eg number of children, number of digits, hairs per unit area – Ordinal whole numbers as opposed to continuous values – Are a special type of quantitative trait • Threshold characteristics – Disease is often considered as a discrete trait • present or absent – However, it can be modelled as a quantitative trait with a threshold above which the classification of disease phenotype is made
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This note was uploaded on 03/10/2008 for the course GENETICS 2007 taught by Professor Gene during the Three '07 term at Griffith.

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8.1 - Module 8 Complex Inheritance George Mellick E-mail [email protected] Telephone 3735 5019(Room N44 2.11 References Chapter 22 of

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