Final_Examw06key

Final_Examw06key - LS4 Final Exam INSTR L Johnson Monday...

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LS4 Final Exam INSTR: L. Johnson Monday, March 20, 2006 NAME:_________________________________ (last) (first) I.D. #__________________________________ INSTRUCTIONS 1. This exam is 11 pages long. PROBLEM VALUE SCORE Before starting make sure you have all the pages. 1 33 2. Be sure to write clearly. Only 2 15 legible answers will be graded. 3 1 0 4 20 5 1 0 6 1 0 7 2 4 8 2 0 9 20 10 18 11 10 12 10 Total 200 KEY
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2 NAME:_________________________________ ID# _______________________ (last) (first) (33 pts) 1. Each of the following unrelated problems is worth 3 pts. No partial credit will be given. Please do your work on scratch paper. Assume homozygosity unless otherwise indicated. a) Imagine you have a plant with 2n = 18. What is the total number of chromatids present during prophase I of meiosis? 36 b) A pure-breeding wild type male fly is mated to a pure-breeding yellow-bodied female. The resulting F1 females are wild type and the males are all yellow- bodied. If the F1 males and females are interbred, what will the ratio of yellow to wild type be in the F2 females? 1:1 c) A pure-breeding blue bird was mated to a pure-breeding green bird. All the F1 were teal. When these were breed, the F2 yielded 14 blue birds, 16 green birds, 48 teal birds, and 5 white birds. How many genes are involved in bird color? 2 genes d) 22 mu separate the autosomal recessive dwarfed and brown-seed in tomatoes. What percent of the gametes of a heterozygote whose recessive alleles are in cis, are wild type? 39% e) If the co-transduction frequency of a and b is 10% and the co-transduction frequency of a and c is 40%, which loci are closer? a-c
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3 NAME:_________________________________ ID# _______________________ (last) (first) f) Alice has been diagnosed with cystic fibrosis, a rare autosomal recessive disorder. Alice’s aunt (her mother’s sister) married her uncle (her father’s brother). They are now expecting their first child. What is the chance it will have cystic fibrosis? 1/16 g) In England, alkaptonuria (autosomal recessive disease) is found at a frequency of 1/100,000. How may heterozygotes would you expect in a population of 100,000? 630 h) At one polymorphic site, there are 5 alleles all found at an equal frequency. What is the chance of an individual being homozygous at this locus? 5(.2)(.2)=.2 i) How can a double stranded RNA lead to a reduction in gene product? dsRNA is cleaved into siRNAs by dicer, which directs RISC complex to the complementary RNA, which is cut by argonaute leading to RNA degradation. j) What is a difference between generalized transduction and specialized transduction? Generalized transduction can move any marker whereas specialized transduction results in the movement of only a few genes. k) Gene knockouts in yeast are generally made in diploid cells.
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This note was uploaded on 07/13/2008 for the course LS 4 taught by Professor Ribaya during the Spring '08 term at UCLA.

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Final_Examw06key - LS4 Final Exam INSTR L Johnson Monday...

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