Fischer - Neuro 4100 lecture Oct 2016_1

Fischer - Neuro 4100 lecture Oct 2016_1 - Andy Fischer...

Info icon This preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Andy Fischer Professor Department of Neuroscience The Ohio State University Glaucoma & Retinitis pigmentosa: Animal models, cell replacement, neuronal survival and retinal regeneration Andy Fischer Professor Department of Neuroscience The Ohio State University Glaucoma & Retinitis pigmentosa: Animal models, cell replacement, neuronal survival and retinal regeneration
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Seminar outline: (1) Prevalence of ocular diseases (2)Background the eye and the retina (3)Diseases of the retina glaucoma, AMD & retinitis pigmentosa (4)Cell replacement therapies (5)Retinal precursors, ES (Embryonic stem) cells and iPSCs (induced Pluripotent Stem Cells) (6)Retinal stem cells or Müller glia as a cellular source of retinal regeneration.
Image of page 2
The progressive loss of neurons from the retina underlies the loss of vision, and eventually blindness, that occurs in prevalent diseases such as macular degeneration, glaucoma and retinitis pigmentosa. Significance and relevance:
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The loss of vision, from retina-related disorders, has a large impact upon health care and quality of life
Image of page 4
The progressive loss of neurons from the retina underlies the loss of vision, and eventually blindness, that occurs in prevalent diseases such as macular degeneration, glaucoma and retinitis pigmentosa. Sight-threatening diseases of the retina can be treated by: (i) Fixing what has gone wrong. (ii) Promoting the survival of retinal neurons. (iii) Replacing the lost neurons with new ones. Significance and relevance:
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Request for input on the NEI RFI for the Audacious Goals Initiative: as of October 2014 This RFI requests input regarding the following areas of concern: 1) The current barriers to identifying and isolating appropriate stem cells for retinal transplants that will produce a sufficient number of functioning photoreceptors and/or retinal ganglion cells to restore visual function. 2) The current challenges to activating endogenous progenitor cells that will mature into a sufficient number of functioning photoreceptors or retinal ganglion cells to restore visual function.
Image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern