Cebulla Retina 2016 - Why don ’ t I see Can neuroscience...

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Why don t I see? Can neuroscience help? Colleen M. Cebulla, MD, PhD Assistant Professor Ocular Oncology and Vitreoretinal Diseases Department of Ophthalmology Neuroscience 4100 October 20, 2015
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Eye as extension of the brain
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Ocular Anatomy
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Retinal Neurons
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Techniques to diagnose visual disorders: mostly noninvasive Pupil exam Fundus photos Optical coherence tomography Fluorescein angiography Visual Field testing • Electrophysiology
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OCT-noninvasive imaging based on coherence of light OCT is to light as ultrasound is to sound • Noninvasive Micron resolution 3 -D
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Optical Coherence Tomography
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Categories of Visual Loss Anterior Segment (Cornea, cataract) • Glaucoma* • Retina* • Neuro-ophthalmology* Oculoplastics* (eyelid and orbital disease) *Important for Neuroscientists!!
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Keratoprosthesis: Artificial Cornea
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Glaucoma is the most common cause of irreversible blindness worldwide
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Half of the people with glaucoma do not even know they have it!
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Glaucoma Fluid enters the front the eye. In certain people the fluid drains too slowly out of the eye causing the fluid to build up and the pressure to increase.
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Glaucoma Diagnosis: A Historical Perspective Pre 1980 s Intraocular pressure (IOP) > 21 = glaucoma • 1980 s to mid 1990 s IOP > 21 + visual field (VF) loss = glaucoma Mid 1990 s to present Glaucomatous optic disc damage = glaucoma
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Definition of Glaucoma A group of disease in which results in optic neuropathy characterized by cupping optic nerve rim loss Optic nerve damage which correlate with visual field loss How can we study this?
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Optic Nerve Cup-to-Disc Ratio Fundus Photos
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Visual Field
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OCT Retina NFL
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