102ch23b - C /a 551' Ff m‘Hda 0W Segment 0F 19.14. 9h...

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Unformatted text preview: C /a 551' Ff m‘Hda 0W Segment 0F 19.14. 9h /oca¥7'aa mt o/I‘Sai-Fid’e bmJSZoccar éer‘ween Q- 635 maIQCu/OS) 60,}! ca,” 1 1 mg-cl-H Mag-lo.” W;- S -$ — c»; 3) {econ/am Sf-rac-I-are greaivFic WI-I‘a/ arrange/m en'f a? 19.14. residue: #6:)“ are a/ose hgefier. 60/1}: a. fagfe/Hde (Maia. alrfie/iz ar fl-f/eafel‘ deer" me {frad'ure o-F Raf-eh: Flgum‘. 02 LI" 3 Primary Structure of Insulin. i958 NobLL @fi 2?; Sanger}: E 3??? w 3333 E Sagorldcm-y Sfiuc{‘u1& @ [5*‘012114'601, Shenjt‘ PERIODIC STRUCTURES: TH'E ALPHA HELIX, BETA PLEATED SHEET. MD COLLAGEN’HEUX - Vic-0.250 5a. 'SR'aQHfi inkfi)‘. \c=o ... H_N/ \czo ... H_N/ Can a pohrpcptidc chain fold into I'Itgulafly mpcating :chturc? / \ / \ To WE! this question, Pauling and Corey evalualcd a variety of H71: C-__'—O --- 11—31 :0 pom-trial polypeptide confnmatimsby building precise molcmlar \ / \ / modelsofthemThcyadhcmdclosdymthccxpcfimmtaflyub- Cm“ “'3 CH?- CHR Whom: ugaumdcusmcuiormimacads andsmallpep— 020/ \N_H m o_c/ \Nfifl dd; 1n i951, they pmpoacd two periodic poly-peptide mm, \ / w \ / callcd the a helix and fl planed shout. N—H-u 0:0 N—H m 02C The a firth: is a rodlikc sanctum. The tightly coilnd polypeptide / \ / \ main chain farms Ibeinncrpan ofthcmd,a.nd the sidcchaim (ti-m CHR GER CHE attend outward Ln a helical array ("Figures 2-3? and 2-38}. Th: :- \ / \ / can-H N c:o H—N / - \ / \ B—N c:o---H—N c=o Wmauumnm \ / \ / raw-237 matthcfidadzflmlmhm] CHE CH5 CH3 CHI! millighhhanckdnbdhz{h)wflydumflommMm mammummmm / \ C/ \ .mmmtmmwmmm(QMm th-lfiiid’lhcllmuchI-F o_.—_C N—H---0_—.._ Nfirfl bmyiarhon(C}ammmshmnc(C)mda-chdh_ bmdamcmmd mmmmmam \ / \ / inpaany---inlud}bcmmmdooyuuplflhfliacthchdix mkumimidtthzhdh. NHH-fl a=c N—H --- 0:6 - ._ r; \‘ ’1 \\ 7 g n c CI-m cam aim [tam c=0mH—N czom H—N / \ / \ 11—?! (3:0 --- H—N :0 \ / \ / Hm“ "-58.01%? “NJ 3) form: r: 57‘ rad'are (Ian‘h'a/ arrange med If residues 'Hafl‘ 62"! fl; flrj ' - fiver-a” polo/{n pal; pep Pd! Me In aFHCe 4). Qua'fernarg $f7~a¢fure flrwl'wfvh pr agsac"¢"£"d.h 010 several fforzez'n Mai/25 [subun:‘+s) I'm‘o a c/ace/y \ . paeéea/ arramjcmem‘ l (file/mo} Io Mn . - E: aw’vms 60/2}? icy/45 of ’7’ Fraulein Pilaf/15 _) Figure 4.24 Shut-hue of tho 5 subunit n5 demyhogjobin. The cylindrical regions men-helical mniamatimlenmedAthmughfii‘im M. £th and L F. 'I Eyck. Cold Spring Harbor Symp. Quant. BioL. as, 296 {19711.} TEQTtAfilf ST’R UCTURE C)? HEMOGLO'ZB w ComSFonJFnj “Fl—{"4 1 . 5 Q9 #5! drug 51's 0F 30 fe in 5 a) Cafe/pried #Zdra/gsl's Show: gaff] 0r M + 5943‘ 6) Ella marl}: Ala/r0! 9/5 Pro+€aéq 6/5 m— £4-6 Whmummww plamnumdthai-un. Eng/cues 667.1%ngth prm‘eoész'; Pro 7’94 $8 5 1) 4m)» 52352142 5;: seguen‘h'a It]; figdrogw Mfel‘mhlls a) [a rbox fidases =«‘7 C— fern»sz: 3) £1240 gee h‘e/a se 5 cleave W/id Mia/'17 - ofir‘m _,, aj- 9/760“ch reg/dyes E ' _. fly] a £1: 9-: Mai ffoa’ttcfs are flfaa’aczed Pg 6M piegr;afif:d2fl 7L M814 by 1,000/9qu a-F Me ice/AM)”; e HJe 5 fr 195/1! .7 Pfie Tyr 7?;2 ff 5‘ y Zea—V L4" —él - 5—$e -6/ Clgmofrzfiw}? .' (*efl/ of afamafi'c 14.”. a i at Z; r a M " (CW 015 édsi'c 14,4,- 1 5 A7 Wild“ are Malta}: 0?. 3' I? Aydfolyw's mt foiwfng [De/0794149 7 a L - . Efi' \l : (Md llama/ads regal/- é, V 6 #“VITJ’PW” H652: fe/SI}? ? flb — éfir Pie - §€r- Vafi- lyi-flb- g9}— 664—141} fl/a- §er— 6/;(- @r- [ea - I/a/ ' affix Defla'fum'foh 01“ Panza)” 105 5 0f a’ész‘mcfih 515 44W»? l ‘ [causes .015 fienavlarm’vm l ———.—-———————-———-—-— £041Pormm‘io-n of: a P/‘N‘W'fl I) #801- => Desi-r225 Acadia» 2) Kg JmfiM ’7“: S'h'acr‘are i 3) flaw,er 30 J, 9) 0X. or fled 3.9 I 51’ 5) fl-Jonding sdvenfs In my cases [7‘ f5 fevers/'Z/e 6) Organic Sofie/17'! I glend'unfih mum‘ara‘HOn 3* g) -———--5 '7) #eaV/ me‘fa/ Sci/*5 ) 55”) ac‘five ina cfivc ‘3 "3 71""3 \ r‘ M, l/aesifl‘cah‘on a? PM Min; : . 3 rmev‘hds e-F alatszfikqh‘n )) Sa/ubi/fllz [in Hz 0) a) G/olm/gr Prér‘er'ns sdaéle in ’4} or 5a” So/n's .L—— 1») PM was meez'n; in $054 5/9 in [112 0 9L) dings/WM. C Frag fiefic firm/s) D 212w [no *8 in 5 Make Praia/375 m fro fem 5 . dram lord-eh; ,3 has 3A0 fwd-em s 3) Shy/a fl Emcr’v'm shawl-“rd - medal:ch “7/”? M z—ymes ) Aormfi‘néfi I , «(a MK I, 4) 5; Z, 5’, m, /6, Wag— .22, 9-6, 9—3, 30J 32, 34/; 35, 39, 443 42) 94—96, 1/2, 5‘0, 51,2 #54 MM ’74 “amino Acid; 4— l’epv‘ides @ ...
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102ch23b - C /a 551' Ff m‘Hda 0W Segment 0F 19.14. 9h...

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